Ultra High Pressure HPP Sterilizer 5L-300L, 300-600MPa
1. Application Demands of Non-Thermal Processing for Medicinal Raw Materials
Traditional processing of Chinese herbal medicines and pharmaceutical raw materials mostly adopts thermal sterilization and hot reflux extraction. Continuous heating may change active ingredient structure, cause loss of heat-sensitive substances and affect raw material composition stability. Many pharmaceutical laboratories and small pilot workshops need equipment that realizes sterilization and component extraction without excessive heating. Laboratory HPP equipment covers tank volumes ranging from 5L to 300L and adjustable pressure parameters between 300MPa and 600MPa. As non-thermal processing equipment relying on ultra-high pressure action, this HPP sterilizer and extraction machine meets the experimental, trial-production and small-batch processing needs of herbal medicine and pharmaceutical raw materials.
2. Working Mechanism of HPP Non-Thermal Treatment Without High Temperature
The whole processing logic of the equipment depends on isostatic ultra-high pressure physical action rather than heat energy. After raw materials are sealed inside flexible packaging and placed into the pressure vessel, pressure transmission media evenly deliver pressure to all parts of samples under set pressure from 300MPa to 600MPa. High pressure damages cell walls of microorganisms to realize microbial inactivation for sterilization purposes. Meanwhile, pressure acts on herbal tissue cells to promote dissolution of intracellular effective ingredients into solvent, completing extraction. The whole reaction process runs under normal or mild temperature conditions, lowering the probability of thermal degradation of flavonoids, alkaloids, vitamins and other heat-sensitive active substances inside medicinal materials.
3. 5L-300L Volume Grading Matches Different Stages of Laboratory Research
The series has diversified tank capacity options from 5L to 300L to adapt to different experimental scales.
Small volume models of 5L to 20L fit daily laboratory small-sample trials, formula screening and parameter exploration. The compact structure occupies limited lab space and facilitates repeated multiple groups of comparative tests.
Medium volumes of 30L to 100L apply to pilot amplification tests, used to verify process stability after laboratory formula confirmation and accumulate production data for formal manufacturing.
Large volumes of 150L to 300L serve small batch trial production of pharmaceutical factories and research institutes, realizing stable continuous feeding and discharging to connect subsequent processing procedures. All volume specifications adopt unified pressure control structure standards.
4. 300–600MPa Adjustable Pressure for Classified Processing of Medicinal Materials
Different herbal varieties and pharmaceutical raw materials differ in cell compactness, target ingredient stability and microbial tolerance, requiring flexible pressure setting.
Pressure within 300MPa to 400MPa is suitable for medicinal materials with fragile active ingredients, such as some flower herbs and enzyme-containing pharmaceutical raw materials. Such pressure can finish basic sterilization and mild extraction while reducing pressure-induced ingredient denaturation.
Pressure ranging 400MPa to 500MPa is the common parameter range for most root and stem Chinese herbal medicines, balancing extraction efficiency and microbial removal effect in regular research.
Pressure from 500MPa to 600MPa can act on raw materials with dense cell structures and high microbial load, helping improve cell rupture degree and lower residual microorganism quantity. Operators can set targeted pressure values according to material test requirements.
5. Structural Design Suited for Laboratory R&D Management
This HPP machine is designed targeting laboratory usage characteristics. The pressure vessel adopts pressure-resistant metal materials with stable mechanical performance under long-time cyclic pressure changes. The control system supports precise adjustment of pressure holding time, boosting speed and circulating times, convenient for researchers to record and optimize process parameters. The equipment body has reasonable layout for easy cleaning and disinfection between batches, avoiding cross-contamination among different medicinal samples. Safety protection structures are configured on pressure holding modules to control risks brought by high-pressure operation during repeated experiments.
6. Multiple Applicable Raw Material Categories and Process Compatibility
The equipment matches diversified processing demands in the pharmaceutical and herbal research fields. It supports sterilization and effective component extraction of common Chinese herbal medicines including ginseng, chrysanthemum, licorice and honeysuckle. It is also applicable to processing of biological pharmaceutical raw materials, plant extracts and heat-sensitive medicinal intermediates. The non-thermal processing mode reserves original characteristic components of raw materials better than high-temperature methods. The machine can independently complete sterilization treatment or extraction operation according to process design, supporting flexible collocation of different experimental schemes.
